Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Age-dependent lens changes in galactose-fed dogs

P A Lackner1, L Rodriguez, S Sato

  • 1Laboratory of Ocular Therapeutics, National Eye Institute, National Institutes of Health, Bethesda, MD 20892, USA.

Experimental Eye Research
|March 1, 1997
PubMed
Summary

Younger dogs rapidly developed severe sugar cataracts when fed galactose, with changes mirroring age-dependent reductions in lenticular NADPH-dependent reductase activity. Cataracts in the youngest dogs showed signs of resorption.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Unravelling groundwater and surface water sources in the Esteros del Iberá Wetland Area: An isotopic approach.

The Science of the total environment·2022
Same author

Lower uterine segment thickness assessed by transvaginal ultrasound before labor induction: reproducibility analysis and relationship with delivery outcome.

Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology·2022
Same author

Moderate to Severe Psoriasis in Pediatric and Young Patients: The BIOBADADERM Registry Experience.

Actas dermo-sifiliograficas·2022
Same author

Allgrove syndrome in a toddler: Alacrima and achalasia, with no adrenal insufficiency.

Revista de gastroenterologia de Mexico (English)·2021
Same author

Allgrove syndrome in a toddler: Alacrima and achalasia, with no adrenal insufficiency.

Revista de gastroenterologia de Mexico (English)·2020
Same author

Changing Trends in Drug Prescription and Causes of Treatment Discontinuation of First Biologic Over Ten Years in Psoriasis in the Spanish Biobadaderm Registry.

Actas dermo-sifiliograficas·2020

Area of Science:

  • Ophthalmology
  • Biochemistry
  • Veterinary Medicine

Background:

  • Sugar-induced cataracts in dogs are initiated by aldose reductase.
  • Previous studies documented cataract progression in 9-month-old galactose-fed dogs.

Purpose of the Study:

  • To investigate the effect of age on the onset and severity of sugar cataract formation.
  • To compare cataract development in beagles fed a galactose diet at different ages (2, 6, and 24 months).

Main Methods:

  • Beagles were fed a 30% galactose diet starting at 2, 6, or 24 months of age.
  • Cataract formation was monitored using slit lamp and retroillumination microscopy.
  • Lenticular NADPH-dependent reductase activity was assessed.

Main Results:

Related Experiment Videos

  • Cataract formation was more rapid and severe in younger dogs compared to 9-month-old controls.
  • In 2-month-old dogs, cataracts formed rapidly, then began to resorb after 106 days.
  • Age-dependent reductions in lenticular NADPH-dependent reductase activity correlated with cataract development.

Conclusions:

  • Age significantly influences the onset and severity of galactose-induced cataracts in dogs.
  • Younger dogs exhibit accelerated cataract formation and potential for resorption.
  • Reduced aldose reductase activity is linked to age-related differences in sugar cataract development.