Related Experiment Videos
Non-organ specific autoantibodies against cellular components in HIV-1 infected individuals
T Kordossis1, L Piha, A Guialis
1Department of Pathophysiology, Medical School of Athens, Greece.
Objective:
To detect the presence of autoantibodies against cellular components in HIV-1 infected individuals.
Methods:
Serum samples from 87 patients with HIV-1 infection and from 17 healthy HIV-seronegative controls were tested using sensitive and specific techniques (immunoblot, RNA precipitation), as well as counterimmunoelectrophoresis and indirect immunofluorescence.
Results:
Four sera (4.6%) showed reactivity in immunoblot against various unidentified cytoplasmic autoantigens. The four positive sera were obtained from patients belonging in equal numbers to the non-AIDS and AIDS groups.
Conclusion:
It appears that the production of antibodies against cellular components rarely occurs during the clinical course of HIV infection.