Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Bacterial interference caused by autoinducing peptide variants

G Ji1, R Beavis, R P Novick

  • 1Skirball Institute of Biomolecular Medicine, New York University Medical Center, New York, NY 10016, USA.

Science (New York, N.Y.)
|June 27, 1997
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Molecular signatures of maladaptive plasticity in the amygdala in a rat model of chronic neuropathic pain.

bioRxiv : the preprint server for biology·2026
Same author

[Comparison of short-term safety and efficacy among total laparoscopic, laparoscopy-assisted, and open radical total gastrectomy after neoadjuvant therapy: a multicenter retrospective study].

Zhonghua wei chang wai ke za zhi = Chinese journal of gastrointestinal surgery·2025
Same author

[A case of transverse colon metastasis caused obstruction during treatment of bone metastasis and lung metastasis after breast cancer].

Zhonghua wei chang wai ke za zhi = Chinese journal of gastrointestinal surgery·2025
Same author

Fecal Microbiota Transplantation Modulates Gut Microbiome Composition and Glial Signaling in Brain and Colon of Rats with Neuropathic Pain: Evidence for Microbiota-Gut-Brain Axis.

The Journal of frailty & aging·2024
Same author

[Comparison of short-term safety of two anastomotic techniques when resecting Siewert type II adenocarcinoma of the esophagogastric junction: a multicenter retrospective cohort study].

Zhonghua wei chang wai ke za zhi = Chinese journal of gastrointestinal surgery·2024
Same author

[Successful treatment of complicated intra-abdominal infection with 13 gastrointestinal leaks:a case report].

Zhonghua wei chang wai ke za zhi = Chinese journal of gastrointestinal surgery·2023
Same journal

Erratum for the Research Article "Detecting supramolecular organic nanoparticles during heat wave".

Science (New York, N.Y.)·2026
Same journal

Local signals, systemic decline.

Science (New York, N.Y.)·2026
Same journal

The mechanics of liver regeneration.

Science (New York, N.Y.)·2026
Same journal

Computing in a memory with physics.

Science (New York, N.Y.)·2026
Same journal

Retraction.

Science (New York, N.Y.)·2026
Same journal

Making time.

Science (New York, N.Y.)·2026
See all related articles

Staphylococcus aureus virulence is regulated by the agr system. Some strains produce peptides that inhibit other strains, suggesting a mechanism for bacterial competition.

Area of Science:

  • Microbiology
  • Bacterial genetics
  • Molecular biology

Background:

  • The agr locus globally controls extracellular protein synthesis in Staphylococcus aureus via a two-component signaling system.
  • The system relies on an autoinducing peptide (AIP) produced by the bacteria.
  • Interactions between different S. aureus strains involving the agr system are not fully understood.

Purpose of the Study:

  • To investigate the mechanism of cross-inhibition of the agr system between different Staphylococcus aureus strains.
  • To explore the role of sequence variation in agr-encoded peptides and receptors.
  • To understand the implications of this cross-inhibition for bacterial competition.

Main Methods:

  • Comparative analysis of agr peptide and receptor sequences across different S. aureus strains.

Related Experiment Videos

  • Assays to determine the inhibitory effects of cognate peptides on heterologous agr expression.
  • Correlation of cross-inhibition patterns with strain characteristics.

    • Main Results:

    • Significant sequence divergence in agr peptides and receptors between strains exhibiting cross-inhibition.
    • Demonstration that cognate peptides from some strains can inhibit agr expression in others.
    • Identification of a hypervariability-generating mechanism within the agr system.

    Conclusions:

    • Cross-inhibition of the agr system is mediated by divergent peptide and receptor sequences.
    • This bacterial interference mechanism may play a role in strain exclusion from host sites.
    • The agr system's variability contributes to S. aureus strain competition and ecological dynamics.