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Rheumatoid neutrophilic dermatitis

H A Mashek1, C T Pham, T N Helm

  • 1Department of Dermatology, State University of New York at Buffalo, USA.

Archives of Dermatology
|June 1, 1997
PubMed
Summary

Rheumatoid neutrophilic dermatitis (RND), a rare skin condition linked to rheumatoid arthritis, presents with neutrophilic infiltration. This study confirms leukocytoclasia can be a striking feature of RND.

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Area of Science:

  • Dermatology
  • Rheumatology
  • Pathology

Background:

  • Rheumatoid neutrophilic dermatitis (RND) is a rare cutaneous manifestation associated with severe rheumatoid arthritis.
  • First described in 1978, RND has been reported in only 8 patients prior to this study.
  • The condition is typically asymptomatic.

Observation:

  • This report details two new cases of RND.
  • Skin biopsies revealed dermal leukocytosis and leukocytoclasia without vasculitis.
  • The exact pathogenesis of the neutrophilic infiltrate remains under investigation, potentially involving immune complexes, cell adhesion, and cytokines.

Findings:

  • The study confirms that leukocytoclasia, a key feature of neutrophilic vascular reactions, can be prominent in RND.
  • Histopathological findings include dermal leukocytosis and leukocytoclasia.
  • These findings align with observations by Lowe et al. regarding leukocytoclasia in RND.

Implications:

  • Dermatologists should be aware of RND as a potential manifestation of rheumatoid arthritis.
  • Recognizing RND is crucial for accurate diagnosis and management of patients with rheumatoid arthritis.
  • This study contributes to understanding neutrophilic vascular reactions within the spectrum of dermatological conditions.

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