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Tissue factor in health and disease
1Department of Biomedical Sciences and Human Oncology, University of Bari, Italy. dimopato@cimedoc.uniba.it
Thrombosis and Haemostasis
|July 1, 1997
Summary
Tissue factor (TF) is crucial for blood coagulation and hemostasis. Inappropriate TF expression by cells like macrophages contributes to pathological conditions such as sepsis-associated disseminated intravascular coagulation (DIC) and cancer progression.
Area of Science:
- Biochemistry
- Hematology
- Pathology
Background:
- Tissue Factor (TF) is vital for initiating blood coagulation in hemostasis.
- TF's perivascular distribution and critical role in hemostasis are well-established.
- TF knockout studies highlight its essential function in vivo.
Purpose of the Study:
- To review the in vivo expression of Tissue Factor (TF) in various physiological and pathological states.
- To explore the role of inappropriate TF expression in diseases like sepsis and thromboembolism.
- To investigate TF's involvement in tumor growth and dissemination in malignancy.
Main Methods:
- Literature review of studies on in vivo TF expression.
- Analysis of TF's role in physiological hemostasis.
- Examination of TF expression in pathological conditions including sepsis and malignancy.
Main Results:
- TF is essential for initiating physiological blood coagulation.
- Inappropriate TF expression by monocyte-macrophages and endothelial cells is linked to pathological fibrin deposition.
- TF expression in tumors contributes to coagulation activation, tumor growth, and metastasis.
Conclusions:
- TF plays a dual role in health (hemostasis) and disease (pathological coagulation and cancer).
- Understanding TF's in vivo expression is critical for developing therapeutic strategies against thrombotic and malignant diseases.
- Targeting TF may offer novel approaches for managing DIC, thromboembolism, and cancer.