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[Allergy to human semen]

A T Dijkstra1, C A Bruijnzeel-Koomen

  • 1Academisch Ziekenhuis, afd. Dermatologie en Allergologie, Utrecht.

Nederlands Tijdschrift Voor Geneeskunde
|April 5, 1997
PubMed
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Two women experienced severe allergic reactions to human semen, including anaphylaxis. Hyposensitization treatment successfully resolved their symptoms, demonstrating its effectiveness for semen allergy.

Area of Science:

  • Reproductive Immunology
  • Allergology
  • Dermatology

Background:

  • Human semen allergy is a rare condition causing significant adverse reactions.
  • Symptoms can range from localized discomfort to life-threatening anaphylaxis.
  • Diagnosis often involves allergy testing and assessment of immunoglobulin E (IgE).

Observation:

  • Two women presented with symptoms including itching, swelling, urticaria, angioedema, and dyspnoea after cohabitation.
  • Elevated total serum IgE levels were noted in both patients.
  • One patient had increased semen albumin-specific IgE, and both reacted positively to seminal plasma intracutaneous testing.

Findings:

  • Both patients were diagnosed with allergy to human semen.
  • Specific IgE antibodies against semen components were detected.

Related Experiment Videos

  • Intracutaneous testing with seminal plasma confirmed hypersensitivity.

    • Implications:

    • Successful hyposensitization therapy can alleviate symptoms of semen allergy.
    • This case highlights the importance of considering semen allergy in patients with unexplained allergic reactions.
    • Further research into the allergens within seminal plasma is warranted.