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Plasma fibrinogen concentration in a Chinese population
1Department of Medicine, The Chinese University of Hong Kong, the Prince of Wales Hospital, Shatin, N.T.
Atherosclerosis
|June 1, 1997
Summary
This study found that higher plasma fibrinogen levels in Chinese adults are linked to increased cardiovascular risk factors like higher BMI, blood pressure, and abnormal lipid and glucose metabolism, particularly triglycerides and HbA1c.
Area of Science:
- Cardiovascular Health
- Metabolic Syndrome
- Clinical Biochemistry
Background:
- Plasma fibrinogen is a known predictor of cardiovascular events.
- Limited data exists on plasma fibrinogen levels in Chinese populations.
- Understanding these levels is crucial for cardiovascular risk assessment in this demographic.
Purpose of the Study:
- To investigate the relationship between plasma fibrinogen concentration and various cardiovascular risk factors in a Chinese cohort.
- To identify specific risk factors independently associated with elevated plasma fibrinogen.
- To provide insights into the role of fibrinogen in cardiovascular disease pathogenesis within this population.
Main Methods:
- A cross-sectional study of 988 Chinese subjects undergoing an oral glucose tolerance test.
- Data collected included plasma fibrinogen, body mass index (BMI), blood pressure (BP), fasting and 2-hour plasma glucose (PG), glycated hemoglobin (HbA1c), and triglyceride (TG) levels.
- Statistical analyses included stratification, adjusted analyses, and multivariate regression.
Main Results:
- Increased plasma fibrinogen was associated with older age, higher BMI, systolic and diastolic BP, fasting and 2-hour PG, diabetes prevalence, HbA1c, and TG levels.
- After adjustments, plasma fibrinogen remained associated with higher BMI, systolic BP, 2-hour PG, and TG.
- Multivariate analysis revealed independent associations between plasma fibrinogen and plasma TG concentration and HbA1c.
Conclusions:
- Plasma fibrinogen concentration is closely related to several cardiovascular risk factors in the studied Chinese population.
- Abnormal lipid and glucose metabolism, specifically elevated triglycerides and HbA1c, are independently associated with higher plasma fibrinogen levels.
- These findings highlight the importance of monitoring fibrinogen in relation to metabolic health for cardiovascular risk stratification in Chinese individuals.