Lymphocyte proliferative responses of goats vaccinated with Brucella melitensis 16M or a delta purE201 strain

¹National Animal Disease Center, Agricultural Research Service, U.S. Department of Agriculture, Ames, Iowa 50010, USA. SOlsen@nadc.ars.usda.com

|July 1, 1997

Abstract:

The response to a Brucella melitensis purEK deletion mutant, delta purE201 (referred to as strain 201), was compared with the response to its parental strain, 16M, in juvenile goats. Proliferative responses to gamma-irradiated bacteria were detected earlier in strain 201-infected goats. Lymphocytes from strain 16M- or 201-infected goats proliferated in response to one-dimensional polyacrylamide gel electrophoresis-separated proteins of similar mass isolated from strain 16M or Brucella abortus RB51. Data from this study suggest that some antigens stimulating cell-mediated responses are conserved among Brucella species, as 201- and 16M-infected goats recognized similar proteins expressed by RB51 and 16M.

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Lymphocyte proliferative responses of goats vaccinated with Brucella melitensis 16M or a delta purE201 strain

Abstract:

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