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Related Experiment Videos

The serum anion gap. Has the reference interval really fallen?

W L Roberts1, R D Johnson

  • 1Department of Pathology, University of Mississippi Medical Center, Jackson 39216, USA.

Archives of Pathology & Laboratory Medicine
|June 1, 1997
PubMed
Summary
This summary is machine-generated.

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Different automated chemistry analyzers yield varying reference intervals for the anion gap (sodium minus chloride and CO2). Laboratories must verify intervals for their specific instruments to ensure accurate diagnosis of acid-base disorders.

Area of Science:

  • Clinical chemistry
  • Medical laboratory science

Background:

  • The anion gap is a calculated value used to assess acid-base balance.
  • Reference intervals for laboratory tests can vary between different analytical instruments.

Purpose of the Study:

  • To compare the anion gap reference intervals across three distinct automated chemistry analyzers.
  • To determine the appropriateness of existing anion gap reference intervals for specific instrumentation.

Main Methods:

  • Serum samples were analyzed for sodium, chloride, and total carbon dioxide on three commercial automated chemistry analyzers.
  • Quality control and proficiency materials were used to ensure optimal analyzer function.
  • Mean and standard deviations of anion gap measurements were calculated for each instrument.

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Main Results:

  • The Beckman Synchron CX3 analyzer yielded a reference interval of 5 to 10 mmol/L.
  • The Boehringer Mannheim Hitachi 717 analyzer showed a reference interval of 9 to 14 mmol/L.
  • The Johnson & Johnson Vitros 950 analyzer produced a reference interval of 8 to 13 mmol/L.

Conclusions:

  • Anion gap reference intervals differ significantly among automated chemistry analyzers.
  • Laboratories should establish and verify anion gap reference intervals specific to their instrumentation.
  • Accurate anion gap reporting is crucial for diagnosing acid-base disorders.