Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Hydroxyapatite ceramics with selected sintering additives

W Suchanek1, M Yashima, M Kakihana

  • 1Materials and Structures Laboratory, Tokyo Institute of Technology, Yokohama, Japan.

Biomaterials
|July 1, 1997
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Autofluorescence (safe) bronchoscopy and p21/ki-67 immunostaining related to carcinogenesis.

Photodiagnosis and photodynamic therapy·2014
Same author

High-Tc nodeless s±-wave superconductivity in (Y,La)FeAsO(1-y) with Tc=50 K:75As-NMR study.

Physical review letters·2012
Same author

Possibility of valence-fluctuatsion-mediated superconductivity in Cd-doped CeIrIn(5) probed by In NQR.

Physical review letters·2012
Same author

Antiferromagnetic spin fluctuations and unconventional nodeless superconductivity in an iron-based new superconductor (Ca4Al2O(6-y))(Fe2As2): 75As nuclear quadrupole resonance study.

Physical review letters·2011
Same author

Structure and electrical properties of the new pyrochlore-type protonic solid electrolyte K(0.88)Nb2O(7.58)H(4.28).

Acta crystallographica. Section B, Structural science·2010
Same author

Spin susceptibility of noncentrosymmetric heavy-fermion superconductor CeIrSi3 under pressure: 29Si Knight-shift study on single crystal.

Physical review letters·2010
Same journal

Corrigendum to "Photodynamic therapy produces enhanced efficacy of antitumor immunotherapy by simultaneously inducing intratumoral release of sorafenib" [Biomaterials 2020, 240, 119845].

Biomaterials·2026
Same journal

Mg-integrated octopus-inspired hydrogel dressing enables autonomous adhesion and wound closure for enhanced healing via sequential microenvironment regulation.

Biomaterials·2026
Same journal

Engineering miRNA-223 nanocomplexes via bioorthogonal self-assembly for precision therapy of intervertebral disc degeneration.

Biomaterials·2026
Same journal

Corrigendum to "Enhanced fluorescence imaging guided photodynamic therapy of sinoporphyrin sodium loaded graphene oxide" [Biomaterials 42 (2015) 16442].

Biomaterials·2026
Same journal

An injectable Ce-MnCo LDH nanozyme gel with cascade catalytic activity for acute radiation proctitis in rats.

Biomaterials·2026
Same journal

Peptide coacervate-mediated siRNA delivery for dual PD-1/PD-L1 blockade to enhance colorectal cancer immunotherapy.

Biomaterials·2026
See all related articles

Researchers explored sintering additives for hydroxyapatite (HA) to improve ceramic properties. Beta-sodium calcium phosphate (β-NaCaPO4) emerged as an effective sintering agent, enhancing densification without HA decomposition or forming unwanted phases.

Area of Science:

  • Biomaterials Science
  • Ceramic Engineering
  • Materials Chemistry

Background:

  • Hydroxyapatite (HA) is a key biomaterial for bone regeneration.
  • Enhancing HA sinterability is crucial for advanced ceramic applications.
  • Sintering additives must maintain HA's bioactivity and biocompatibility.

Purpose of the Study:

  • To identify effective sintering additives for hydroxyapatite (HA).
  • To evaluate additives' impact on HA densification, phase composition, and microstructure.
  • To ensure additives do not compromise HA's bioactivity and biocompatibility.

Main Methods:

  • Selection of ion species from hard tissues and bioactive glasses.
  • Investigation of CaO-P2O5-additive phase diagrams and additive properties.

Related Experiment Videos

  • Sintering HA with 5 wt% additives at 1000-1100°C, followed by analysis of densification, phase composition, grain growth, and fracture behavior.

    • Main Results:

    • Several additives (H3BO3, CaCl2, KCl, KH2PO4, (KPO3)n, Na2Si2O5) failed to enhance HA densification.
    • K2CO3, Na2CO3, KF, and sodium phosphates significantly improved densification.
    • Most additives formed undesirable beta-tricalcium phosphate or CaO, except KCl and controlled sodium phosphates.
    • Beta-sodium calcium phosphate (β-NaCaPO4) proved effective, avoiding HA decomposition and undesired phase formation.

    Conclusions:

    • Beta-sodium calcium phosphate (β-NaCaPO4) is a promising sintering agent for hydroxyapatite.
    • Careful control of additive quantity and composition is vital for sodium phosphates.
    • Effective sintering aids can be developed from ions found in biological minerals.