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Computerized videokeratography of keratoconus kindreds
G L Morrow1, R M Stein, J S Racine
1Department of Ophthalmology, Mount Sinai Hospital, University of Toronto, Ont.
Summary
Heredity plays a significant role in keratoconus development. Videokeratography identified early signs in relatives, suggesting an autosomal dominant inheritance pattern for this corneal condition.
Area of Science:
- Ophthalmology
- Genetics
- Corneal Diseases
Background:
- Keratoconus is a progressive thinning of the cornea.
- The exact cause of keratoconus is not fully understood, but genetic factors are suspected.
- Early diagnosis and understanding of inheritance patterns are crucial for management.
Purpose of the Study:
- To investigate the role of heredity in the development of keratoconus.
- To identify potential genetic markers or inheritance patterns in families with keratoconus.
- To assess the utility of videokeratography in diagnosing subclinical cases within families.
Main Methods:
- A prospective study was conducted at an eye clinic.
- 39 patients with keratoconus and 48 relatives were evaluated.
- Corneal topography using videokeratography was compared between family members and 68 controls.
Main Results:
- Fifteen family members, appearing clinically normal, showed significant topographic abnormalities indicative of early or mild keratoconus.
- These subclinical findings suggest incomplete gene expression in relatives.
- Statistical analysis revealed significant differences in corneal topography.
Conclusions:
- Heredity is a significant factor in keratoconus development.
- An autosomal dominant inheritance pattern was suggested in most families studied.
- Videokeratography is a valuable tool for family pedigree analysis and early keratoconus diagnosis.