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Related Experiment Videos

Fractures after thyroidectomy in men: a population-based cohort study

T T Nguyen1, H Heath, S C Bryant

  • 1Division of Endocrinology and Internal Medicine, Mayo Clinic, Rochester, Minnesota, USA.

Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research
|July 1, 1997
PubMed
Summary

Thyroidectomy in men does not significantly increase overall fracture risk. However, a higher incidence of hip fractures was observed, warranting further investigation into this specific outcome.

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Area of Science:

  • Endocrinology
  • Orthopedics
  • Gerontology

Background:

  • Thyroid hormone excess or calcitonin deficiency may reduce bone mass.
  • Thyroidectomy's impact on fracture risk, particularly in men, is not well-established.
  • Previous studies often focused on women, potentially confounding results with involutional osteoporosis.

Purpose of the Study:

  • To evaluate the fracture risk in men following thyroidectomy.
  • To compare fracture incidence in thyroidectomized men versus age-matched controls.

Main Methods:

  • Retrospective cohort study of 136 men who underwent thyroidectomy (1935-1979) in Rochester, Minnesota.
  • Comparison with age-matched community controls.
  • Follow-up period of 2194 person-years for each group.

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  • Assessment of fractures of the vertebra, proximal humerus, distal forearm, pelvis, or proximal femur.

    • Main Results:

    • Overall fracture-free survival was similar between thyroidectomized men and controls (p = 0.23).
    • The relative risk of any fracture was a 1.5-fold increase in thyroidectomized patients (95% CI, 0.7-3.2).
    • A statistically significant excess of proximal femur (hip) fractures was observed in the thyroidectomized group.
    • Risk factors for fractures in thyroidectomized men included older age at surgery, greater extent of surgery, and secondary osteoporosis risk factors.

    Conclusions:

    • Thyroidectomy, primarily for adenoma or goiter, appears to have minimal overall impact on age-related fracture risk in men.
    • The increased risk of hip fractures following thyroidectomy requires further investigation.
    • Risk stratification for fractures in post-thyroidectomy men should consider age at surgery and secondary osteoporosis.