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Renal angiotensin-converting enzyme localization in diabetic rats and the effect of low protein diet
S Mizuiri1, M Kobayashi, T Nakanishi
1Department of Nephrology, Toho University School of Medicine, Ohta-ku Tokyo, Japan.
Nephron
|January 1, 1997
Abstract:
Recent evidence suggests a role of angiotensin-converting enzyme (ACE) in diabetic nephropathy. The effect of diabetes and low protein diet on renal immunohistochemical ACE localization was studied in streptozotocin-induced DM rats. Immunohistochemical ACE localization was reduced in DM rats, and a low protein diet partially resolved this abnormality while inhibiting the progression of diabetic nephropathy.