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Updated: Feb 8, 2026

Immunoglobulin G N-Glycan Analysis by Ultra-Performance Liquid Chromatography
Published on: January 18, 2020
Determination of acyclovir in human plasma by high-performance liquid chromatography
R Boulieu1, C Gallant, N Silberstein
1Institut des Sciences Pharmaceutiques et Biologiques, Laboratoire de Pharmacie Clinique et d'Evaluation du Médicament, Lyon, France.
Abstract:
A selective and sensitive isocratic high-performance liquid chromatographic method for the analysis of acyclovir in human plasma was described. Acid deproteinisation was used as sample treatment. Mean analytical recoveries were higher than 94% at low and high concentrations. The quantification limit was 0.1 mg/l for a plasma volume of 500 microl and precision study exhibits coefficients of variation lower than 5%. The method is suitable for therapeutic monitoring of acyclovir concentrations in organ-transplant recipients.
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