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Circadian rhythms in mouse suprachiasmatic nucleus explants on multimicroelectrode plates
E D Herzog1, M E Geusz, S B Khalsa
1University of Virginia, Department of Biology, Center for Biological Timing, Charlottesville 22903, USA. edh3f@virginia.edu
Brain Research
|May 23, 1997
Abstract:
The suprachiasmatic nucleus (SCN) of the mammalian hypothalamus functions as a circadian pacemaker. This study used multimicroelectrode plates to measure extracellular action potential activity simultaneously from multiple sites within the cultured mouse SCN. Neurons within the isolated mouse SCN expressed a circadian rhythm in spontaneous firing rate for weeks in culture.