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A novel device for capturing breath samples for solvent analysis

D Dyne1, J Cocker, H K Wilson

  • 1Health and Safety Executive, London, England.

The Science of the Total Environment
|June 20, 1997
PubMed
Summary
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A new breath sampler collects end-tidal air for analysis of solvents using automated thermal desorption-gas chromatography-mass spectrometry (ATD-GCMS). This sensitive and reproducible method enables non-invasive monitoring of solvent exposure and elimination in various industries and human volunteers.

Area of Science:

  • Environmental Health
  • Analytical Chemistry
  • Occupational Medicine

Background:

  • Occupational exposure to volatile organic compounds (VOCs) poses health risks.
  • Monitoring solvent levels in exhaled breath offers a non-invasive assessment method.
  • Existing breath analysis techniques can be complex or lack sensitivity.

Purpose of the Study:

  • To develop and validate a novel breath sampling device for end-tidal air.
  • To assess the device's sensitivity, reproducibility, and ease of use in diverse settings.
  • To quantify solvent exposure and elimination in industrial environments and human volunteers.

Main Methods:

  • Development of a breath sampling device for end-tidal air collection.
  • Analysis of breath samples using automated thermal desorption-gas chromatography-mass spectrometry (ATD-GCMS).

Related Experiment Videos

  • Laboratory validation, field trials in industries, and human volunteer studies.

    • Main Results:

    • The method demonstrated high sensitivity (detection limit of 1 nmol/l) and reproducibility (5-15% CV).
    • Field trials successfully identified and quantified solvents like tetrachloroethene and ethyl acetate in industrial settings.
    • Over 500 breath samples from 24 volunteers exposed to 10 different solvents were analyzed, showing effective monitoring of solvent elimination.

    Conclusions:

    • The novel breath sampler provides a reliable, sensitive, and non-invasive tool for assessing occupational solvent exposure.
    • The ATD-GCMS analysis of end-tidal air is effective for monitoring solvent uptake and elimination.
    • This technology has significant potential for improving workplace safety and health surveillance.