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[Endogenous retroviruses in autoimmune diseases]
1Department of Pathology, Hokkaido University School of Medicine.
Nihon Rinsho. Japanese Journal of Clinical Medicine
|June 1, 1997
Summary
Endogenous retroviruses (ERVs) can trigger immune system issues and autoimmune diseases by affecting gene expression or acting as auto-antigens. This review covers ERV roles in animal and human immunological disorders.
Area of Science:
- Genomics
- Immunology
- Virology
Context:
- Endogenous retroviruses (ERVs) are genetic elements integrated into host genomes.
- ERVs can influence host gene expression and protein production.
- Their activity in immune cells can lead to immunological dysregulation.
Purpose:
- To review current research on endogenous retroviruses (ERVs).
- To explore the connection between ERVs and immunological disorders, including autoimmune diseases.
- To provide examples of ERV involvement in autoimmunity.
Summary:
- ERVs, originating from retroviral integrations or transposable elements, can impact host biology.
- Mechanisms include altered gene expression and production of regulatory proteins or auto-antigens.
- Dysregulation of immune networks by ERVs can precipitate autoimmune conditions.
Impact:
- Highlights the significant role of ERVs in the pathogenesis of autoimmune diseases.
- Provides a foundation for understanding ERV-mediated autoimmunity.
- Suggests potential targets for therapeutic interventions in autoimmune disorders.