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Alteration of dopamine D2 receptors in human malignant stomach tissue
1Department of Medical Oncology, Chittaranjan National Cancer Institute, Calcutta, India.
Abstract:
Dopamine is an important enteric neurotransmitter with a wide spectrum of physiological actions on the gastrointestinal tract. In addition, it showed inhibition of malignant cell proliferation as well as a protective influence on experimental carcinogenesis in the gastrointestinal tract of murine hosts. It is well established that dopamine acts on target cells through specific receptors. Therefore the status of dopamine receptors in malignant tumors of the stomach has been evaluated. Normal, benign, and malignant stomach tissue showed the presence of high-affinity D2 dopamine receptors. The concentration (Bmax) and affinity (Kd) of dopamine binding sites in normal and benign tumor tissues were similar. In malignant stomach tissue Bmax showed a significant decrease compared to normal and benign controls; however, Kd was similar. This alteration of dopamine receptors may be of significance in understanding the etiopathogenesis of gastric cancer at the level of peripheral neurotransmitters. Rational use of dopamine receptor antagonists for various stomach diseases may be suggested.
Insights
Dopamine D2 receptors are present in stomach tissues, but their concentration decreases in malignant tumors. This finding may impact understanding gastric cancer development and treatment strategies.
Area of Science:
- Gastroenterology
- Neuroscience
- Oncology
Background:
- Dopamine is a key enteric neurotransmitter influencing gastrointestinal functions.
- Dopamine exhibits anti-proliferative effects on malignant cells and protective roles in carcinogenesis.
- Dopamine exerts its effects via specific dopamine receptors on target cells.
Purpose of the Study:
- To evaluate the status of dopamine receptors in normal, benign, and malignant stomach tissues.
- To investigate alterations in dopamine receptor concentration and affinity in gastric cancer.
Main Methods:
- Analysis of high-affinity D2 dopamine receptors in human stomach tissues.
- Quantification of dopamine binding site concentration (Bmax) and affinity (Kd).
Main Results:
- High-affinity D2 dopamine receptors were detected in normal, benign, and malignant stomach tissues.
- Dopamine receptor concentration (Bmax) was significantly decreased in malignant tissues compared to normal and benign tissues.
- Dopamine receptor affinity (Kd) remained similar across all tissue types.
Conclusions:
- Alterations in D2 dopamine receptor status, specifically decreased Bmax, may play a role in gastric cancer pathogenesis.
- Findings suggest potential therapeutic implications for dopamine receptor antagonists in stomach diseases.
- Further research into peripheral neurotransmitter roles in gastric cancer is warranted.