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The spinal abnormalities in thalidomide embryopathy

D H Edwards, P J Nichols

Acta Orthopaedica Scandinavica

|January 1, 1977

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Thalidomide exposure in children with congenital abnormalities frequently causes spinal issues. Most affected children developed scoliosis or disc and end-plate abnormalities, some progressing over time.

Area of Science:

Pediatric Orthopedics
Teratology
Radiology

Background:

Thalidomide, a teratogen, is known to cause multiple congenital abnormalities.
Spinal deformities are a potential consequence of developmental abnormalities.

Purpose of the Study:

To investigate the long-term spinal changes in children with thalidomide-induced congenital abnormalities.
To assess the prevalence and progression of spinal conditions in this cohort.

Main Methods:

Retrospective review of spinal radiography in 28 children previously identified with thalidomide embryopathy.
Radiographic assessment for scoliosis, disc abnormalities, and end-plate changes.

Main Results:

Only 4 out of 28 children had normal spines.

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Scoliosis was observed in 8 children, showing mild progression.

Disc and end-plate abnormalities were present in 14 children, with some cases demonstrating progressive changes leading to intervertebral fusion.

Conclusions:

Children with thalidomide embryopathy frequently exhibit significant spinal abnormalities.
Progressive spinal changes, including scoliosis and disc/end-plate issues, are common and may lead to fusion.