Nuclear bodies in laryngeal papilloma

Electron microscopy of Juvenile Laryngeal Papilloma from Nigerian children has revealed the presence of nuclear bodies in the neoplastic cells. These bodies were round or oval in shape and varied from 0.3 to 0.5 micrometer in diameter. The immature forms consisted of fine fibrous units, whereas the mature forms displayed central and peripheral zones. The central zone consisted of dense, coarse, granular filaments, whereas the peripheral zone showed fine filaments of low electron density. Some intermediate forms were also noted. These bodies were similar to those reported in other viral infections and in tumour cells.