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Related Experiment Videos

Does continuous heparinization influence platelet function in the intensive care patient?

J Boldt1, M Müller, A Rothe

  • 1Department of Anesthesiology and Intensive Care Medicine, Justus-Liebig-University Giessen, Germany.

Intensive Care Medicine
|May 1, 1997
PubMed
Summary
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Continuous heparin administration at approximately 500 U/h did not impair platelet function in intensive care trauma patients. Sepsis patients showed recovery of platelet function, unaffected by heparin, indicating safety for intensive care patients.

Area of Science:

  • Critical Care Medicine
  • Hematology
  • Pharmacology

Background:

  • Platelet dysfunction is common in critically ill patients.
  • The impact of continuous heparin administration on platelet function in intensive care settings requires clarification.

Purpose of the Study:

  • To investigate the effects of continuous unfractionated heparin on platelet aggregation in intensive care unit (ICU) patients.

Main Methods:

  • Prospective study involving 45 ICU patients (sepsis, trauma, neurosurgery).
  • Platelet aggregation measured using turbidimetric methods with ADP, collagen, and epinephrine.
  • Coagulation parameters, including platelet count, fibrinogen, and antithrombin III, were monitored.

Main Results:

Related Experiment Videos

  • Continuous heparin (approx. 500 U/h) did not decrease platelet counts in sepsis or trauma patients.
  • Sepsis patients showed initial decreases in platelet aggregation, followed by recovery exceeding baseline values.
  • Heparinized trauma patients maintained stable platelet aggregation, comparable to untreated neurosurgical patients.

    • Conclusions:

    • Continuous heparinization at approximately 500 U/h appears safe for platelet function in ICU patients.
    • Heparin did not negatively influence platelet function in trauma patients.
    • Heparin did not impede the recovery of platelet function in sepsis patients.