Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Measuring renal function in patients with diabetes mellitus

A McElduff1, B Shuter, R Cooper

  • 1Department of Endocrinology, Royal North Shore Hospital, St. Leonards, New South Wales, Australia.

Journal of Diabetes and Its Complications
|July 1, 1997
PubMed
Summary

Estimating glomerular filtration rate in diabetic patients is challenging. Measured creatinine clearance lacked reproducibility, while calculated methods underestimated plasma ethylenediaminetetra-acetic acid clearance.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Colorectal cancer T stage, size at diagnosis, and presentation 2017 to 2023: an analysis using Veterans Affairs data.

Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract·2026
Same author

Impact of single-use waste reduction initiatives using citizen science data: Western Australia as a case study.

Marine pollution bulletin·2025
Same author

A qualitative exploration of women's experiences of food insecurity around pregnancy aligned with the socio-ecological model.

Appetite·2025
Same author

A service evaluation following the implementation of computer guided consultation software to support primary care reviews for chronic obstructive pulmonary disease.

NPJ primary care respiratory medicine·2025
Same author

'It's especially good just to know that you're not the only one': a qualitative study exploring experiences with online peer support programmes for the Fragile X community.

Journal of intellectual disability research : JIDR·2024
Same author

Simultaneous implementation of unrelated tumour sites on the MR Linac: A review of the commissioning process from a radiographer perspective and lessons learned.

Journal of medical imaging and radiation sciences·2024

Area of Science:

  • Nephrology
  • Diabetology
  • Clinical Chemistry

Background:

  • Accurate estimation of glomerular filtration rate (GFR) is crucial for managing diabetic patients.
  • Current methods for GFR assessment in routine clinical practice present challenges in reproducibility and accuracy.
  • Diabetic nephropathy can significantly alter renal function, necessitating reliable GFR measurement.

Purpose of the Study:

  • To compare the accuracy and reproducibility of three methods for estimating GFR in diabetic patients.
  • To evaluate the correlation between measured creatinine clearance, calculated creatinine clearance (Cockcroft and Gault), and plasma ethylenediaminetetra-acetic acid ([51Cr]EDTA) clearance.
  • To determine the suitability of these methods for routine clinical use in a diabetic population.

Main Methods:

Related Experiment Videos

  • Glomerular filtration rate was estimated in 33 diabetic patients using three methods: measured creatinine clearance, calculated creatinine clearance (Cockcroft and Gault), and [51Cr]EDTA plasma clearance.
  • Measurements were repeated in seven subjects to assess reproducibility.
  • Statistical analysis was performed to compare the results obtained from the different methods.

Main Results:

  • Measured creatinine clearance demonstrated poor reproducibility.
  • Calculated creatinine clearance and [51Cr]EDTA clearance showed correlation but not identity (y=x).
  • Calculated creatinine clearance significantly underestimated [51Cr]EDTA clearance, especially at higher clearance rates.

Conclusions:

  • Routine clinical measurement of glomerular filtration rate in diabetic patients using creatinine-based methods is unreliable.
  • Plasma [51Cr]EDTA clearance offers a more reproducible alternative but may underestimate true GFR.
  • Clinical decisions based on current GFR measurements in diabetic patients should be made with caution due to method limitations.