Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Monitoring brain tumor response to therapy using MRI segmentation

M Vaidyanathan1, L P Clarke, L O Hall

  • 1Department of Radiology, University of South Florida, Tampa 33612, USA.

Magnetic Resonance Imaging
|January 1, 1997
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Clinical outcomes of closed versus open simple ankle fractures patterns requiring soft tissue reconstruction: A prospective comparative observational study.

Foot and ankle surgery : official journal of the European Society of Foot and Ankle Surgeons·2025
Same author

How confident are UK radiographers at performing paediatric computed tomography trauma scans?

Radiography (London, England : 1995)·2023
Same author

αvβ8 integrin-expression by BATF3-dependent dendritic cells facilitates early IgA responses to Rotavirus.

Mucosal immunology·2020
Same author

Blastomycosis presenting as multiple splenic masses.

The Canadian journal of infectious diseases = Journal canadien des maladies infectieuses·2012
Same author

Primary central-nervous-system lymphoma - treatment with multiagent systemic and intrathecal chemotherapy with radiation-therapy.

International journal of oncology·2011
Same author

Herpes-zoster and procarbazine therapy in patients with malignant glioma.

International journal of oncology·2011

This study evaluated the semi-supervised fuzzy c-means (SFCM) method for brain tumor volume monitoring. SFCM and kNN multispectral methods are preferred for assessing relative tumor volume changes during treatment.

Area of Science:

  • Radiology and Medical Imaging
  • Computational Biology
  • Oncology

Background:

  • Accurate monitoring of brain tumor volume changes is crucial for evaluating treatment efficacy during radiation and chemotherapy.
  • Existing methods for tumor volume segmentation present challenges in reproducibility and accuracy, especially after treatment.

Purpose of the Study:

  • To evaluate the performance of a semi-supervised fuzzy c-means (SFCM) clustering method for monitoring brain tumor volume changes.
  • To compare SFCM with k-nearest neighbor (kNN), intensity-based seed growing (ISG-SG), and ground truth (GT) manual labeling methods.
  • To assess the reproducibility and accuracy of these methods for both absolute and relative tumor volume measurements.

Main Methods:

  • SFCM and kNN methods were applied to multispectral MRI (T1, proton density, T2 weighted).

Related Experiment Videos

  • ISG-SG and GT methods were applied to contrast-enhanced T1-weighted MRI only.
  • Volume estimations were performed on eight patient cases with follow-up MRI scans over 32 weeks, including meningioma, brain metastases, and gliomas.

    • Main Results:

    • Limited agreement was found between segmentation methods for absolute tumor volume measurements post-treatment.
    • Average intraobserver reproducibility was 5.8% (SFCM), 6.6% (kNN), and 8.9% (ISG-SG).
    • Average interobserver reproducibility was 5.5% (SFCM), 6.5% (kNN), and 11.4% (ISG-SG).

    Conclusions:

    • Multispectral methods, specifically kNN and SFCM, are preferred for measuring relative changes in tumor volume for treatment response assessment.
    • SFCM demonstrates good reproducibility for brain tumor volume monitoring.
    • Further validation is needed for absolute volume measurements in post-treatment scenarios.