Transplantable lymphoma producing type K Bence-Jones protein in NZB mouse

Spontaneous lymphoma occurring in the retroperitoneum in a 13-month-old New Zealand Black female mouse, as transplantable to the same strain mice, was subjected to immunological studies by serial transplantation as subcutaneous solid tumor (66A) and bloody ascites tumor (66B). The transplanted tumor-bearing mice showed M component in the plasma, urine and ascites. It was confirmed as type K Bence-Jones protein. Speculations were made on the relation between abnormal immunity in NZB mice and lymphoma.