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DNA-variations in neighbouring epithelium in patients with bladder carcinoma
Abstract:
Histologically atypical urothelium taken from bladder mucosa neighbouring transitional cell carcinoma showed similar, though less marked, DNA-changes as observed in the corresponding tumours. A definite increase in the number of non-diploid DNA-values was found in 6 (of 12 urothelial specimens. The clinical significance of urothelial DNA-changes is discussed.