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[Diabetes mellitus and ischemic heart disease: case-control study]
1Departamento de Epidemiologia da Faculdade de Saúde Pública, Universidade de São Paulo, Brasil. samoraes@usp.br
Revista De Saude Publica
|August 1, 1996
Summary
Diabetes is not an independent risk factor for ischaemic heart disease (IHD). Major risk factors like hypertension and smoking were identified, and their inclusion in the analysis explained the lack of association with diabetes.
Area of Science:
- Cardiology
- Endocrinology
- Epidemiology
Context:
- Diabetes mellitus is frequently cited as an independent risk factor for ischaemic heart disease (IHD).
- Methodological variations across studies hinder comparative analysis of diabetes and IHD risk.
- This study addresses the association between diabetes and IHD, accounting for confounding factors.
Purpose:
- To investigate the independent association between diabetes and ischaemic heart disease (IHD).
- To adjust for known confounders and effect modifiers in the relationship between diabetes and IHD.
- To clarify the role of diabetes as a risk factor for IHD in the context of other cardiovascular risk factors.
Summary:
- A case-control study involving 833 adults (30-69 years) in S. Paulo, Brazil, analyzed the association between diabetes and IHD.
- Logistic regression revealed that diabetes was not an independent risk factor for IHD after adjusting for hypertension, hypercholesterolemia, smoking, and family history.
- The study highlights the importance of major cardiovascular risk factors, suggesting their presence diminishes the apparent association with diabetes.
Impact:
- Identifies hypertension, hypercholesterolemia, smoking, and family history as significant independent risk factors for IHD.
- Provides evidence that the association between diabetes and IHD may be confounded by other prevalent risk factors.
- Contributes to a clearer understanding of cardiovascular disease etiology and risk factor management.