Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Corticofugal modulation of frequency processing in bat auditory system

Y Zhang1, N Suga, J Yan

  • 1Department of Biology, Washington University, St Louis, Missouri 63130, USA.

Nature
|June 26, 1997
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Mitochondrial DNA mutation m.3243A>G is associated with altered mitochondrial function in peripheral blood mononuclear cells, with heteroplasmy levels and with clinical phenotypes.

Diabetic medicine : a journal of the British Diabetic Association·2018
Same author

Sleep Quality and Related Psychosocial Variables Among Renal Transplant Patients.

Transplantation proceedings·2018
Same author

[Correlation of transcutaneous oxygen pressure and blood lactate in patients with septic shock].

Zhonghua nei ke za zhi·2018
Same author

[Establishment of zebrafish model for non-alcoholic steatohepatitis].

Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology·2018
Same author

Magnetic resonance spectroscopy may serve as a presurgical predictor of somatostatin analog therapy response in patients with growth hormone-secreting pituitary macroadenomas.

Journal of endocrinological investigation·2018
Same author

[Economic burden of hepatitis C patients and related influencing factors in Guangdong province].

Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi·2018

Descending auditory pathways sharpen frequency tuning. Corticofugal projections from the cortex to subcortical regions enhance frequency selectivity by modulating neuronal responses, improving auditory processing.

Area of Science:

  • Neuroscience
  • Auditory System Research
  • Sensory Processing

Background:

  • Auditory signals travel from the inner ear to higher brain regions.
  • Neurons in the auditory system exhibit frequency tuning and topographical mapping.
  • Ascending projections are traditionally thought to shape these properties.

Purpose of the Study:

  • To investigate the role of descending corticofugal projections in auditory frequency tuning.
  • To determine if corticofugal pathways influence subcortical neuronal responses related to frequency.

Main Methods:

  • Inactivation of specific frequency-tuned cortical neurons in bats.
  • Recording and analysis of subcortical neuronal responses to auditory stimuli.
  • Examination of changes in neuronal tuning and response magnitudes.

Related Experiment Videos

Main Results:

  • Inactivating cortical neurons reduced responses in subcortical neurons tuned to the same frequency.
  • Responses of other subcortical neurons increased, with preferred frequencies shifting towards the inactivated cortical neurons.
  • Demonstrated a positive feedback mechanism mediated by corticofugal projections.

Conclusions:

  • Corticofugal projections play a crucial role in sharpening and adjusting frequency tuning in the auditory system.
  • This descending pathway interacts with ascending pathways and lateral inhibition to refine auditory processing.
  • Highlights the importance of descending pathways in common auditory functions, not just specialized processing.