Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Function and organization in dysgenic cortex. Case report

M C Preul1, R Leblanc, F Cendes

  • 1McConnell Brain Imaging Centre, Department of Neurology and Neurosurgery, Montreal Neurological Institute and Hospital, McGill University, Quebec, Canada.

Journal of Neurosurgery
|July 1, 1997
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Fellowship education in epilepsy in Latin America and Africa: Results of a survey.

Epilepsy & behavior : E&B·2024
Same author

Neurophysiology, Neuropsychology, and Epilepsy, in 2022: Hills We Have Climbed and Hills Ahead. Neurophysiology in epilepsy.

Epilepsy & behavior : E&B·2023
Same author

Modulating Expression of Endogenous Interleukin 1 Beta in the Acute Phase of the Pilocarpine Model of Epilepsy May Change Animal Survival.

Cellular and molecular neurobiology·2022
Same author

Patterning Chronic Active Demyelination in Slowly Expanding/Evolving White Matter MS Lesions.

AJNR. American journal of neuroradiology·2020
Same author

Hippocampal Sclerosis Detection with NeuroQuant Compared with Neuroradiologists.

AJNR. American journal of neuroradiology·2020
Same author

Comparison of Multiple Sclerosis Cortical Lesion Types Detected by Multicontrast 3T and 7T MRI.

AJNR. American journal of neuroradiology·2019
Same journal

Extent of resection as an independent predictor of survival for patients with glioblastoma as defined by the new WHO 2021 classification.

Journal of neurosurgery·2026
Same journal

Surgical treatment of schwannomas around the tarsal tunnel: a case series of 40 patients and systematic review of the literature.

Journal of neurosurgery·2026
Same journal

Direct targeting for focused ultrasound thalamotomy in the treatment of movement disorders.

Journal of neurosurgery·2026
Same journal

Development and internal validation of the Meningioma Functional Outcome Risk and Counseling Estimator 6 score, a point-based prognostic tool for predicting 6-week functional independence after intracranial meningioma resection.

Journal of neurosurgery·2026
Same journal

Connectional anatomy of the cerebellum: dentate nucleus and cerebellar peduncles from a surgical perspective.

Journal of neurosurgery·2026
Same journal

Press releases in neurosurgery: is scientific accuracy compromised in public reporting of neurosurgery research?

Journal of neurosurgery·2026
See all related articles

Cerebral dysgenesis, a developmental brain disorder, can present with significant structural abnormalities. Despite altered organization, some brain regions may maintain normal function, highlighting the need for advanced imaging and mapping before surgery.

Area of Science:

  • Neuroscience
  • Developmental Neuroscience
  • Epileptology

Background:

  • Cerebral dysgenesis is linked to abnormal brain development and neurological dysfunction, particularly epilepsy.
  • Understanding the functional capacity of dysgenic brain tissue is crucial for surgical planning.

Observation:

  • A 16-year-old patient with severe seizures presented with right hemisphere dysgenesis, including nodular gray matter heterotopia and cortical dysplasia.
  • Advanced neurological studies were performed, including magnetic resonance (MR) imaging, positron emission tomography (PET), and MR spectroscopic (1H-MRS) imaging.

Findings:

  • Despite significant cytoarchitectonic and metabolic alterations, large areas of heterotopia and cortical dysplasia retained normal motor and sensory function.
  • Compensatory cortical reorganization was evident, suggesting functional plasticity in dysgenic brain regions.

Related Experiment Videos

Implications:

  • Functional imaging and intraoperative cortical mapping are essential to prevent neurological deficits during surgery for cerebral dysgenesis.
  • Integrated studies like PET, 1H-MRS, and electrophysiology offer valuable insights into the function of developmental brain disorders.