Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Interactions between neuronal histamine and halothane anesthesia in rats

T Mammoto1, Y Yamamoto, K Kagawa

  • 1Department of Anesthesiology, Osaka University, Faculty of Medicine, Suita, Japan.

Journal of Neurochemistry
|July 1, 1997
PubMed
Summary

Halothane anesthesia reduces histamine release in the brain. Histamine signaling via H1 and H2 receptors influences anesthetic requirements, impacting the minimum alveolar concentration (MAC).

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Inhibitory effect of prostaglandin E1 on gastric secretion during general anesthesia in humans.

Journal of anesthesia·2013
Same author

Extracorporeal membrane oxygenation and tracheobronchial foreign body in an infant.

Journal of anesthesia·2013
Same author

Regulation of basophilic and erythroid-differentiation of a human chronic myelogenous leukemia-cell line, ku812f, by interleukin-3 and stem-cell factor.

International journal of oncology·2011
Same author

The antiarrhythmic effect of centrally administered rilmenidine involves muscarinic receptors, protein kinase C and mitochondrial signalling pathways.

British journal of pharmacology·2008
Same author

A possible mechanism of alpha-fluoromethylhistidine-induced increase of food intake.

Inflammation research : official journal of the European Histamine Research Society ... [et al.]·2004
Same author

Thioperamide-elicited increase of histamine release from basolateral amygdala of freely moving rats and its therapeutic implications.

Inflammation research : official journal of the European Histamine Research Society ... [et al.]·2004

Area of Science:

  • Neuroscience
  • Anesthesiology
  • Pharmacology

Background:

  • Neuronal histamine plays a role in regulating physiological functions.
  • The effect of halothane anesthesia on histamine release in the anterior hypothalamic area (AHy) is not fully understood.

Purpose of the Study:

  • To investigate the impact of halothane anesthesia on histamine release in the AHy.
  • To determine the role of histaminergic pathways in modulating the anesthetic effects of halothane.

Main Methods:

  • In vivo microdialysis was used to measure histamine release in rat AHy under varying halothane concentrations.
  • Pharmacological agents including histidine decarboxylase inhibitor, H1 antagonist (pyrilamine), H2 antagonist (zolantidine), and H3 antagonist (thioperamide) were administered.

Related Experiment Videos

Main Results:

  • Halothane anesthesia significantly inhibited histamine release in the AHy.
  • Histamine release inhibition correlated with reduced anesthetic requirement (minimum alveolar concentration, MAC).
  • H1 and H2 receptor antagonists decreased the MAC for halothane, while H3 antagonist had no effect on histamine release or MAC under anesthesia.

Conclusions:

  • Halothane anesthesia suppresses neuronal histamine release.
  • Histaminergic activity, mediated by H1 and H2 receptors, modulates the anesthetic potency of halothane.
  • These findings suggest a role for histamine in anesthetic drug action.