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Related Experiment Videos

Hormonal responses during tilt-table test in neurally mediated syncope

G N Theodorakis1, M Markianos, E G Livanis

  • 12nd Department of Cardiology, Onassis Cardiac Surgery Center and Eginition Hospital, Athens University Medical School, Greece.

The American Journal of Cardiology
|June 15, 1997
PubMed
Summary

Tilt testing revealed increased growth hormones cortisol and prolactin during syncope in patients. This suggests central serotonergic activation plays a role in the fainting episodes.

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Area of Science:

  • Endocrinology
  • Neuroscience
  • Cardiology

Background:

  • Syncope, or fainting, is a common clinical event.
  • The underlying neurohormonal mechanisms of syncope are not fully understood.
  • Hormonal responses during syncope require further investigation.

Purpose of the Study:

  • To investigate the hormonal profile of patients experiencing syncope during tilt testing.
  • To explore the potential role of central serotonergic pathways in syncope.

Main Methods:

  • Hormonal levels were measured in syncopal patients undergoing head-up tilt table testing.
  • Specific focus on growth hormones, including cortisol and prolactin.

Main Results:

  • An increase in cortisol levels was observed during syncopal episodes.

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  • Elevated prolactin levels were also detected during syncope.
  • These hormonal changes suggest a link to central nervous system activation.

    • Conclusions:

    • The study indicates a hormonal shift during syncope, involving cortisol and prolactin.
    • Findings suggest that central serotonergic activation may be implicated in the pathophysiology of syncope.
    • Further research is warranted to elucidate the precise role of these hormones and pathways.