Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Growth factor-dependent phosphoinositide signalling

J J Hsuan1, S H Tan

  • 1Ludwig Institute for Cancer Research, University college London Medical School, U.K.

The International Journal of Biochemistry & Cell Biology
|March 1, 1997
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A cross-sectional study on the second victim experience and support at Sarawak General Hospital: A tertiary public hospital in Borneo Island, Malaysia.

The Medical journal of Malaysia·2025
Same author

Antiviral activity of povidone-iodine gargle and mouthwash solution against Enterovirus A71, Coxsackieviruses A16, A10 and A6.

Tropical biomedicine·2024
Same author

Gemcitabine, carboplatin, and Epstein-Barr virus-specific autologous cytotoxic T lymphocytes for recurrent or metastatic nasopharyngeal carcinoma: VANCE, an international randomized phase III trial.

Annals of oncology : official journal of the European Society for Medical Oncology·2024
Same author

[Characteristics of the tumor microenvironment and therapeutic progress in malignant pleural effusion].

Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases·2024
Same author

Narrow band imaging for sulcus vocalis-an often missed diagnosis.

QJM : monthly journal of the Association of Physicians·2022
Same author

Prevalence and burden of skin diseases among the elderly in Singapore: a 15-year clinical cohort study.

Journal of the European Academy of Dermatology and Venereology : JEADV·2022
Same journal

Corrigendum to "Sodium butyrate down-regulation of indoleamine 2, 3-dioxygenase at the transcriptional and post-transcriptional levels" [Int. J. Biochem. Cell Biol. 42 (2010) 1840-1846].

The international journal of biochemistry & cell biology·2026
Same journal

Whole-brain spatial metabolomics reveals metabolic gradient shifts in a murine glioma model following boron neutron capture therapy (130 characters).

The international journal of biochemistry & cell biology·2026
Same journal

LCN2 modulates Th17/Treg balance in vitro and is associated with an adaptive response to intestinal ischemia-reperfusion injury under Hmox1-deficient conditions.

The international journal of biochemistry & cell biology·2026
Same journal

Chloroquine modulates the redox-sensitive signalling via inhibiting the AMPK-ULK1 under LPS induced state in murine splenic macrophages.

The international journal of biochemistry & cell biology·2026
Same journal

The vicious cycle of hyperglycemia and oxidative stress: Novel mechanistic insights into a pathogenic alliance.

The international journal of biochemistry & cell biology·2026
Same journal

Fibroblast growth factors (FGF) in the pathogenesis and treatment of inflammatory bowel diseases (IBD): An overview.

The international journal of biochemistry & cell biology·2026
See all related articles

Cellular communication relies on signaling pathways, coordinating cell functions like proliferation and metabolism. Understanding receptor-mediated signaling, such as with epidermal growth factor (EGF), is key to deciphering cell behavior and correcting dysfunctions.

Area of Science:

  • Cellular Biology
  • Molecular Signaling
  • Biochemistry

Background:

  • Multicellular organisms use diffusible messengers (growth factors, hormones, cytokines) to coordinate physiological processes.
  • Cellular responses are initiated by messenger binding to cognate receptors, triggering intracellular reaction cascades.
  • The specific cellular response depends on the type and number of surface receptors and downstream signaling components.

Purpose of the Study:

  • To elucidate the molecular mechanisms underlying receptor-mediated cellular signaling.
  • To illustrate general principles of signal transduction using the epidermal growth factor (EGF) receptor pathway as a paradigm.
  • To provide a framework for understanding and correcting cellular dysfunctions through molecular insights.

Main Methods:

Related Experiment Videos

  • Focuses on the well-studied epidermal growth factor (EGF) receptor signaling pathway.
  • Examines primary signaling events at the cytoplasmic leaflet of the plasma membrane post-receptor activation.
  • Discusses the phosphorylation and hydrolysis of phosphatidylinositol initiated by EGF receptor activation.

Main Results:

  • The EGF receptor activates signaling cascades involving enzyme complexes.
  • Second messengers and intermediates are compartmentalized within the cell.
  • Cross-talk occurs between different intracellular signaling pathways.

Conclusions:

  • Molecular understanding of receptor signaling pathways is crucial for rationalizing cellular functions.
  • The EGF receptor pathway exemplifies key signaling principles, including complex formation and messenger compartmentalization.
  • Insights into signaling pathways are essential for correcting cellular dysfunctions.