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Occurrence of myeloproliferative disorder in patients with Noonan syndrome

B Bader-Meunier1, G Tchernia, F Miélot

  • 1Department of Pediatrics, Bicêtre Hospital, Le Kremlin Bicêtre, France.

The Journal of Pediatrics
|June 1, 1997
PubMed

We report four cases of Noonan syndrome associated with chronic myelomonocytic leukemia in childhood. These children shared some hematologic features: thrombocytopenia, splenomegaly in the first months of life, occurrence of chronic myelomonocytic leukemia without abnormalities of the initial bone marrow karyotype, and, in three cases, improvement of the hematologic disease. A common pathophysiologic process in such patients is suggested.

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