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A rat model of spontaneously arrested hydrocephalus. A behavioural study
1Department of Neurosurgery, Juntendo University School of Medicine, Tokyo, Japan.
Abstract:
HTX rats with congenital hydrocephalus that survived for more than 2 months are termed spontaneously arrested hydrocephalic rats. These rats showed impairment in learning, a reverse light-dark discrimination task in a Y-maze. A clear relationship between learning impairment and ventricular dilatation was observed in spontaneously arrested hydrocephalic animals. The usefulness and limitations of HTX-rats as an animal model of spontaneously arrested hydrocephalus are discussed.