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Risk factors for left ventricular hypertrophy in chronic hemodialysis patients

M Washio1, S Okuda, T Mizoue

  • 1Second Department of Internal Medicine, Faculty of Medicine, Kyushu University, Fukuoka, Japan.

Clinical Nephrology
|June 1, 1997
PubMed

Insights

Left ventricular hypertrophy is common in chronic hemodialysis patients. Hypertension and anemia are identified as independent risk factors contributing to this condition, impacting patient mortality.

Area of Science:

  • Nephrology
  • Cardiology
  • Internal Medicine

Background:

  • Left ventricular hypertrophy (LVH) is a prevalent condition in patients undergoing chronic hemodialysis.
  • LVH is associated with an increased risk of mortality in this patient population.

Purpose of the Study:

  • To investigate the independent risk factors for left ventricular hypertrophy (LVH) in non-diabetic chronic hemodialysis patients.
  • To identify clinical and echocardiographical predictors of LVH in the absence of valvular disease or myocardial infarction.

Main Methods:

  • An echocardiographical and clinical study was conducted involving 151 non-diabetic chronic hemodialysis patients.
  • Multivariate analysis was employed to assess correlations between left ventricular mass index (LVMI) and various clinical parameters.

Main Results:

  • Left ventricular mass index (LVMI) showed positive correlations with age, systolic blood pressure, and interdialysis weight gain.
  • LVMI demonstrated negative correlations with the duration of hemodialysis therapy and hematocrit levels.
  • Multivariate analysis confirmed age, systolic blood pressure, duration of hemodialysis, and hematocrit as significant factors influencing LVMI.

Conclusions:

  • Hypertension, indicated by elevated systolic blood pressure, is an independent risk factor for left ventricular hypertrophy in chronic hemodialysis patients.
  • Anemia, reflected by lower hematocrit levels, is also identified as an independent risk factor for LVH in this cohort.
  • These findings underscore the importance of managing blood pressure and anemia to mitigate LVH risk in chronic hemodialysis patients.

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