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17alpha-Dihydroequilenin increases hippocampal dendritic spine density of ovariectomized rats
S A Washburn1, C E Lewis, J E Johnson
1Department of Obstetrics and Gynecology, Bowman Gray School of Medicine, Winston-Salem, NC 27157-1040, USA.
Brain Research
|May 30, 1997
Abstract:
The effects of estradiol and 17alpha-dihydroequilenin on the apical dendrite spine density of pyramidal cells of the CA1 region of rat hippocampus were compared. 17alpha-Dihydroequilenin was as effective as estradiol in increasing spine densities relative to controls. 17alpha-Dihydroequilenin is not uterotrophic like estradiol but does have beneficial effects on the cardiovascular system, suggesting that it may be an effective single-agent hormone replacement therapy to treat menopausal symptoms and reduce chronic disease risk in menopausal women.