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Positron emission tomography in drug development

R H Rubin1, A J Fischman

  • 1Center for Experimental Pharmacology and Therapeutics, Harvard-MIT Division of Health Sciences and Technology, Gordon and Marjorie Osborne Chair of Health Sciences and Technology, Cambridge 02142, USA.

The Quarterly Journal of Nuclear Medicine : Official Publication of the Italian Association of Nuclear Medicine (AIMN) [And] the International Association of Radiopharmacology (IAR)
|June 1, 1997
PubMed
Summary

Positron emission tomography (PET) offers four key measurements to enhance drug development. These PET imaging techniques improve dose selection, identify clinical uses, and link pharmacokinetics with pharmacodynamics for effective therapeutic discovery.

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Area of Science:

  • Pharmacology
  • Medical Imaging
  • Drug Development

Background:

  • Drug development relies on understanding drug behavior and effects in the body.
  • Positron emission tomography (PET) is an advanced imaging technique with potential applications in pharmaceutical research.

Purpose of the Study:

  • To outline the significant contributions of Positron Emission Tomography (PET) in various stages of drug development.
  • To highlight how PET-based measurements can optimize therapeutic strategies.

Main Methods:

  • Utilizing Positron Emission Tomography (PET) for four distinct types of measurements:
  • Quantifying drug-induced tissue metabolism (pharmacodynamics).
  • Measuring tissue blood flow.
  • Assessing drug pharmacokinetics after dosing.

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  • Tracking ligand-receptor interactions over time.

    • Main Results:

    • PET measurements provide crucial data for informed decision-making in drug development.
    • These include optimizing drug dosage and identifying suitable clinical applications.
    • PET facilitates the critical link between pharmacokinetics and pharmacodynamics.

    Conclusions:

    • Positron Emission Tomography (PET) significantly enhances the drug development process.
    • The utility of PET increases with the therapeutic potential of a drug candidate.
    • PET-guided development leads to more effective and targeted therapies.