Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

High-dose UVA1 radiation therapy for localized scleroderma

H Stege1, M Berneburg, S Humke

  • 1Department of Dermatology, Heinrich-Heine-University, Düsseldorf, Germany.

Journal of the American Academy of Dermatology
|June 1, 1997
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Phototesting in dermatology].

Dermatologie (Heidelberg, Germany)·2026
Same author

[Treatment of actinic keratoses in older adults].

Dermatologie (Heidelberg, Germany)·2023
Same author

[UV phototherapy : UV phototherapy and photodiagnostics-a practical overview].

Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete·2021
Same author

[Wound healing].

Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete·2020
Same author

[Wound treatment in diabetes patients and diabetic foot ulcers].

Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete·2020
Same author

Identification of factors associated with minimal erythema dose variations in a large-scale population study of 22 146 subjects.

Journal of the European Academy of Dermatology and Venereology : JEADV·2020
Same journal

Hypoactive Sexual Desire Disorder in Menopausal Women: Dermatologic Implications of Antiandrogen and Testosterone Therapy.

Journal of the American Academy of Dermatology·2026
Same journal

Incise parallel, section perpendicular to the dermatoglyphs for diagnosis of acral melanocytic lesions-A comment on Thakker et al.

Journal of the American Academy of Dermatology·2026
Same journal

Response to Xue et al, "Defining super-responders is not the same as predicting rituximab response in pemphigus".

Journal of the American Academy of Dermatology·2026
Same journal

Comment on Nie et al. (2026) 'Suicidality Reports in Acne Patients Treated with Isotretinoin and Concomitant Antidepressants: A Descriptive Analysis of FDA Adverse Event Reporting System Data'.

Journal of the American Academy of Dermatology·2026
Same journal

Defining super-responders is not the same as predicting rituximab response in pemphigus.

Journal of the American Academy of Dermatology·2026
Same journal

Eosinophilic fasciitis induced by checkpoint inhibitors: a retrospective multicenter case-series, comparison with eosinophilic fasciitis unrelated to checkpoint inhibition and literature review.

Journal of the American Academy of Dermatology·2026
See all related articles

High-dose UVA1 radiation therapy effectively treats localized scleroderma by increasing collagenase I expression, softening skin lesions, and improving elasticity. This dose-dependent therapy offers a promising new treatment for fibrotic skin conditions.

Area of Science:

  • Dermatology
  • Photomedicine
  • Fibrotic Diseases

Background:

  • Localized scleroderma causes disfigurement and contractures due to fibrotic skin lesions.
  • Current treatments for localized scleroderma are ineffective.
  • Skin fibrosis is linked to reduced collagenase activity, which can be boosted by UVA1 irradiation.

Purpose of the Study:

  • To evaluate the efficacy of UVA1 radiation therapy for localized scleroderma patients.

Main Methods:

  • 17 patients with localized scleroderma received either high-dose (130 J/cm2) or low-dose (20 J/cm2) UVA1 therapy over 30 sessions.
  • Effectiveness was measured by clinical assessment, plaque thickness, and skin elasticity.
  • Collagenase I messenger RNA (mRNA) expression in biopsy samples was analyzed.

Related Experiment Videos

Main Results:

  • High-dose UVA1 therapy softened sclerotic plaques in all patients, with complete clearance in 40%.
  • Significant improvements in plaque thickness and elasticity were observed with high-dose UVA1, persisting for at least 3 months.
  • High-dose UVA1 therapy demonstrated superior efficacy compared to low-dose UVA1 (p = 0.001) and increased collagenase I mRNA by approximately 20-fold.

Conclusions:

  • High-dose UVA1 radiation therapy is an effective treatment for localized scleroderma.
  • Treatment efficacy is dependent on the UVA1 dose.
  • The therapeutic effect is associated with the induction of collagenase I expression.