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Bath-5-methoxypsoralen-UVA therapy for psoriasis
P G Calzavara-Pinton1, C Zane, A Carlino
1Department of Dermatology, Brescia University Hospital, Italy.
Journal of the American Academy of Dermatology
|June 1, 1997
Summary
Bath 5-methoxypsoralen (5-MOP) and 8-methoxypsoralen (8-MOP) were compared for psoriasis photochemotherapy. Bath 5-MOP-UVA showed greater phototoxicity and was more effective for palmar psoriasis.
Area of Science:
- Dermatology
- Photobiology
- Pharmacology
Background:
- Oral 5-methoxypsoralen (5-MOP) and 8-methoxypsoralen (8-MOP) are effective for psoriasis PUVA therapy.
- Oral 5-MOP has fewer acute cutaneous side effects compared to 8-MOP.
Purpose of the Study:
- To compare the efficacy and phototoxicity of bath-water delivered 5-MOP and 8-MOP for psoriasis photochemotherapy.
- To evaluate treatment outcomes for palmar and plaque-type psoriasis using these two agents.
Main Methods:
- Phototesting was performed on 22 patients using 0.0003% aqueous solutions of 5-MOP and 8-MOP.
- Twelve patients with palmar psoriasis underwent side-to-side comparison, while 10 with plaque-type psoriasis received one therapy.
Main Results:
- Bath 5-MOP-UVA demonstrated higher phototoxicity (lower minimal phototoxic dose) than bath 8-MOP-UVA.
- Both therapies cleared palmar lesions, but 8-MOP required more UVA irradiation and exposures.
- Bath 5-MOP-UVA led to significantly earlier tanning compared to 8-MOP.
Conclusions:
- Bath 5-MOP-UVA is more phototoxic and effective for palmar psoriasis than bath 8-MOP-UVA.
- Increased pigmentogenic activity of 5-MOP may adversely affect its efficacy in plaque-type psoriasis treatment.