Related Experiment Video
Updated: Aug 12, 2026

Thermal Ablation for the Treatment of Abdominal Tumors
Published on: March 7, 2011
5-fluorouracil iontophoretic therapy for Bowen's disease
M L Welch1, W J Grabski, M L McCollough
1Dermatology Service, Walter Reed Army Medical Center, Washington, USA.
Background:
Topical 5-fluorouracil (5-FU) is an accepted therapy for Bowen's disease. Recurrences with this method have been attributed to deep follicular involvement and poor patient compliance because of the prolonged treatment time required.
Objective:
We sought to determine whether iontophoresis of 5-FU is an effective therapy for Bowen's disease.
Methods:
Twenty-six patients with biopsy-proven Bowen's disease received eight 5-FU iontophoretic treatments in 4 weeks. Local excision was done 3 months after the last treatment. The specimens were step-sectioned and evaluated for any histologic evidence of bowenoid changes.
Results:
Only 1 of 26 patients showed histologic evidence of Bowen's disease 3 months after treatment.
Conclusion:
5-FU iontophoresis appears to be a safe, effective, and well-tolerated therapy for Bowen's disease.
More Related Videos
Related Concept Videos
Drugs for Peptic Ulcer Disease: Sucralfate as Mucosal Protective Agents
In this scenario, mucosal protective agents like sucralfate play an essential role. Sucralfate, a complex of sulfated sucrose and aluminum hydroxide, demonstrates its usefulness in acidic conditions,...
Drugs for Treatment of Diarrhea-Predominant IBS
Two specific drugs used in the treatment are alosetron (Lotronex) and eluxadoline (Viberzi). Alosetron, a 5-HT3 antagonist, works by slowing the movement of stools in the gut, reducing bowel...
Drugs for Treatment of Constipation-Predominant IBS
Drugs for Treatment of Ulcerative Colitis in IBD
Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents
Inflammatory Bowel Disease IV: Pharmacological Management
Pharmacologic...

