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Redox signal transduction via iron-sulfur clusters in the SoxR transcription activator
1Department of Molecular and Cellular Toxicology, Harvard School of Public Health, Boston, MA 02115, USA.
Trends in Biochemical Sciences
|June 1, 1997
Abstract:
Protein iron-sulfur (FeS) centers have recently been implicated in the regulation of gene expression. In the redox-sensing SoxR protein, the oxidation state of [2Fe-2S] centers controls its activity as a transcription activator independent of DNA-binding ability. Thus, FeS centers allosterically link cellular oxidative stress to the expression of defense genes.