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Updated: Sep 23, 2026

Combining X-Ray Crystallography with Small Angle X-Ray Scattering to Model Unstructured Regions of Nsa1 from S. Cerevisiae
09:15

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A crystal milestone: the structure of regulated Src

G Superti-Furga1, S Gonfloni

  • 1European Molecular Biology Laboratory, Heidelberg, Germany.

Bioessays : News and Reviews in Molecular, Cellular and Developmental Biology
|June 1, 1997
PubMed

Insights

The Src protein tyrosine kinases are crucial in cancer and signal transduction research. Recent crystal structures advance understanding of protein phosphorylation and cell growth control.

Area of Science:

  • Oncology
  • Molecular Biology
  • Biochemistry

Background:

  • The Src protein tyrosine kinases (PTKs) are fundamental to signal transduction and cancer research.
  • Their study has historically advanced the fields of protein phosphorylation and cellular growth control.

Purpose of the Study:

  • To highlight the pivotal role of Src PTKs in oncology and signal transduction.
  • To underscore the significance of recent crystal structure determinations for the Src family.

Main Methods:

  • Review of existing literature on Src PTKs.
  • Analysis of the impact of recent crystal structure data.

Main Results:

  • Src PTKs have a long history of 'firsts' in biological research.
  • The crystal structures of two Src family members mark a significant advancement.

Conclusions:

  • The study of Src PTKs serves as a benchmark for progress in phosphorylation and growth control.
  • Emerging structural data offers new perspectives for future research in these areas.

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