Related Experiment Video
Updated: Jul 21, 2026
10:25
Assessment of Lymphocyte Migration in an Ex Vivo Transmigration System
Published on: September 20, 2019
Urinary leukotriene E4 levels in patients with atopic dermatitis
J E Sansom1, G W Taylor, C T Dollery
1University of Bristol, Department of Dermatology, Bristol Royal Infirmary, UK.
The British Journal of Dermatology
|May 1, 1997
Summary
Urinary leukotriene E4 (LTE4) levels were not elevated during atopic dermatitis flares. This study suggests cysteine leukotrienes are not involved in the pathogenesis of atopic dermatitis.
Area of Science:
- Biochemistry
- Immunology
- Dermatology
Background:
- Leukotriene synthesis is implicated in various inflammatory conditions.
- Urinary leukotriene E4 (LTE4) is a metabolite of leukotrienes C4 and D4.
- Elevated urinary LTE4 has been observed in severe asthma exacerbations and after antigen inhalation.
Purpose of the Study:
- To investigate urinary LTE4 levels in patients experiencing severe atopic dermatitis flares.
- To determine if cysteine leukotrienes play a role in the pathogenesis of atopic dermatitis.
Main Methods:
- Measurement of urinary LTE4 levels in seven patients during and after acute atopic dermatitis exacerbations.
- Utilized high-performance liquid chromatography (HPLC) and radioimmunoassay (RIA) for LTE4 quantification.
Main Results:
- Mean urinary LTE4 levels during the flare (16.7 +/- 3.7 pg/mumol) were not significantly increased compared to baseline or normal ranges.
- Mean urinary LTE4 levels after the flare (16.9 +/- 4.8 pg/mumol) also showed no significant elevation.
- Compared to the normal range (mean = 23.8 pg/mumol creatinine), measured levels were not higher.
Conclusions:
- The study found no evidence of increased urinary LTE4 during or after severe atopic dermatitis flares.
- These findings do not support the involvement of cysteine leukotrienes in the pathogenesis of atopic dermatitis.
More Related Videos
Related Concept Videos
01:20Asthma: Pathogenesis and Management
Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
01:19Antiasthma Drugs: Leukotriene Modifiers
Leukotriene modifiers, or cysteinyl leukotriene receptor antagonists, are medications used to manage chronic asthma. These agents target specific inflammatory mediators produced during arachidonic acid metabolism, an essential process in generating inflammation in the body.
Leukotriene modifiers work through two distinct mechanisms:
Leukotriene modifiers work through two distinct mechanisms:
01:30Asthma-IV: Diagnostic and Management
The diagnosis and management of asthma are comprehensive, encompassing clinical assessments, lung function tests, and pharmacological interventions. Here's an overview:
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:
01:28Asthma I: Introduction
Asthma is a chronic inflammatory disorder of the airways characterized by variable airflow obstruction and heightened bronchial responsiveness to a wide range of triggers. The underlying inflammation leads to airway swelling, mucus hypersecretion, and smooth muscle constriction, all of which narrow the airway lumen and impede airflow. Clinically, asthma presents with recurrent episodes of wheezing, shortness of breath, chest tightness, and coughing, symptoms that typically vary in intensity and...
01:13Asthma III: Clinical Manifestations
Asthma presents with a characteristic pattern of episodic respiratory symptoms that reflect underlying airway inflammation, bronchoconstriction, and mucus hypersecretion. Although severity varies among individuals, certain clinical manifestations are considered hallmarks of the disorder and often guide diagnosis and assessment.Respiratory SymptomsA persistent cough is one of the most common early features of asthma. It is frequently dry and tends to worsen at night or in the early morning,...
01:19Chronic Obstructive Pulmonary Disease IV: Clinical Manifestations
Chronic Obstructive Pulmonary Disease, or COPD, is a long-term condition marked by persistent and only partially reversible airflow limitation. It involves two overlapping conditions—chronic bronchitis and emphysema—which often co-appear but differ in dominant symptoms and underlying mechanisms.Chronic Bronchitis FeaturesChronic bronchitis presents with a persistent productive cough and thick, sometimes purulent mucus due to airway inflammation, enlarged mucus glands, and goblet cell...