Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[The jimpy mouse]

O Robain

    Acta Zoologica Et Pathologica Antverpiensia
    |August 1, 1977
    PubMed
    Summary
    This summary is machine-generated.

    Jimpy mice exhibit a severe lack of myelin in the central nervous system due to impaired oligodendrocyte maturation and axonal growth. This myelin deficiency, particularly in late-myelinating regions, suggests an early interruption of the myelination process.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Heterotopia associated with hippocampal sclerosis: an under-recognized cause of early onset epilepsy in children operated on for temporal lobe epilepsy.

    Neuropediatrics·2010
    Same author

    Pontoneocerebellar hypoplasia: definition of MR features.

    Pediatric radiology·2001
    Same author

    Immunocytochemical characterization of long-term persistent immune activation in human brain after herpes simplex encephalitis.

    Neuropathology and applied neurobiology·2000
    Same author

    Increased density of oligodendrocytes in childhood ataxia with diffuse central hypomyelination (CACH) syndrome: neuropathological and biochemical study of two cases.

    Acta neuropathologica·1999
    Same author

    [Cortical heterotopias: animal models and human disease].

    Revue neurologique·1999
    Same author

    Focal cortical dysplasia and hemimegalencephaly: histological and neuroimaging correlations.

    Pediatric radiology·1998
    Same journal

    [Legislation on the control and toxicity of chemical products].

    Acta zoologica et pathologica Antverpiensia·1980
    Same journal

    Microscopic pathology of liver of capuchin monkey (Cebus albifrons) infected with Athesmia foxi (dicrocoelidae : trematoda) : a pictorial illustration.

    Acta zoologica et pathologica Antverpiensia·1980
    Same journal

    [Comparative study of the chemical composition of excrement from some large African herbivorous mammals].

    Acta zoologica et pathologica Antverpiensia·1980
    Same journal

    Analysis of the urine of the okapi (Okapia johnstoni).

    Acta zoologica et pathologica Antverpiensia·1980
    Same journal

    [Estimation of the teratogenic effects of therapeutic drugs].

    Acta zoologica et pathologica Antverpiensia·1980
    Same journal

    [Methods used for the in vivo study of the mutagenic properties of chemical substances].

    Acta zoologica et pathologica Antverpiensia·1980
    See all related articles

    Area of Science:

    • Neuroscience
    • Cell Biology
    • Developmental Biology

    Context:

    • The Jimpy mouse model is utilized to investigate genetic disorders affecting myelin.
    • Understanding the cellular and molecular basis of myelin formation is crucial for neurological health.

    Purpose:

    • To conduct an ultrastructural analysis of the Jimpy mouse central nervous system.
    • To identify the specific cellular defects contributing to the observed hypomyelination.

    Summary:

    • Ultrastructural examination of Jimpy mice reveals a profound lack of central nervous system myelin.
    • Key findings include a low density of glial cells, defective oligodendrocyte maturation, and impaired axonal growth.
    • The hypomyelination is most pronounced in the corpus callosum and corticospinal fasciculus, indicating a failure in late myelination stages.

    Related Experiment Videos

    Impact:

    • This study elucidates the cellular pathology underlying the Jimpy mouse phenotype, offering insights into myelination failure.
    • The findings suggest that the primary issue is an early interruption of myelination rather than secondary demyelination.
    • This research contributes to understanding the complex processes of myelin development and potential therapeutic targets for myelin disorders.