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Synthesis and antimycobacterial activity of nitroxanthones. 1st communication: synthesis and differential scanning
1Department of Pharmacy, Faculty of Chemistry, University of Freiburg, Germany.
Arzneimittel-Forschung
|May 1, 1997
Abstract:
The syntheses of mono-; di-, tri- and tetranitroxanthones via intramolecular Friedel-Crafts acylation of nitrated 2-phenoxybenzoic acids as well as via selective stepwise nitration of xanthone and the nitroxanthones gained from the first route are described. The synthesized nitroxanthones investigated by DSC (differential scanning calorimetry) analysis show a surprisingly high thermodynamic stability which was confirmed by quantum chemical calculations.