School age outcome in low birth weight preterm infants
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Updated: Nov 1, 2026

Assessment and Evaluation of the High Risk Neonate: The NICU Network Neurobehavioral Scale
Published on: August 25, 2014
1Department of Pediatrics, University of California, San Francisco 94143, USA.
Insights
Very low birth weight (VLBW) children often face school challenges despite normalized early health. Social factors significantly influence VLBW children's academic outcomes, overshadowing medical risks.
Area of Science:
- Pediatrics
- Developmental Psychology
- Neuroscience
Background:
- Very low birth weight (VLBW) children exhibit varied school-age outcomes compared to normal birth weight peers.
- Early physical and health disparities often diminish by middle childhood.
- Previous studies indicate higher rates of school retention and problems in non-handicapped VLBW children.
Purpose of the Study:
- To investigate the relationship between central nervous system (CNS) status and school-age outcomes in VLBW children.
- To explore the relevance of CNS status for learning disabilities and neuropsychological deficits.
- To understand the interplay of medical risk factors and social influences on VLBW children's academic performance.
Main Methods:
- Analysis of school-age outcomes in VLBW children born in the late 1970s and early 1980s.
- Correlation of academic performance with central nervous system (CNS) status.
- Examination of socioeconomic factors, such as parental education, confounding intelligence assessments.
Main Results:
- Variability in school-age outcomes persists in VLBW children.
- Intelligence differences in VLBW children are often linked to socioeconomic factors.
- Central nervous system (CNS) status is a potentially relevant, yet understudied, factor for VLBW school-age outcomes.
Conclusions:
- Social factors exert a decisive influence on the expression of VLBW children's school-age outcomes.
- Understanding medical risk factors alone is insufficient without considering social determinants.
- Further research is needed to explore the CNS-outcome link in VLBW populations.
Abstract:
Very low birth weight (VLBW) children at school age show variability in their outcome, compared with normal birth weight children, although many early physical and health differences are equalized by middle childhood. Studies of nonhandicapped VLBW children have found a higher rate of school retention and school problems in this population. Differences in intelligence have been reported, although these are often confounded by socioeconomic factors such as educational level of the parent. Few studies today of children born in the late 1970s and early 1980s have related school age outcome to central nervous system (CNS) status, yet for learning disabilities or other neuropsychological deficits, this may be highly relevant. Better understanding of medical risk factors, however, will not affect the decisive influence of social factors on their expression in the school age child.
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