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[Experimental study on delayed effect of external skin expansion]
Zhonghua Zheng Xing Shao Shang Wai Ke Za Zhi = Zhonghua Zheng Xing Shao Shang Waikf [I.E. Waike] Zazhi = Chinese Journal of Plastic Surgery and Burns
|May 1, 1996
Summary
External skin expansion enhances skin microcirculation and vascularization, similar to delayed flaps. This technique improves the survival area of expanded skin without compromising its quality.
Area of Science:
- Plastic Surgery
- Tissue Engineering
- Microcirculation Research
Context:
- External skin expanders are used to increase skin surface area for reconstructive purposes.
- The physiological mechanisms underlying skin expansion, particularly its effect on microcirculation and vascularity, require further elucidation.
- Comparing skin expansion to established techniques like delayed flaps is crucial for understanding its efficacy.
Purpose:
- To investigate the mechanism by which external skin expanders affect skin microcirculation and vascularity.
- To compare the efficacy of external skin expansion with the delay flap technique in terms of skin survival and vascularization.
- To assess the quality of expanded skin for potential clinical applications.
Summary:
- 20 New Zealand rabbits were divided into experimental (skin expansion) and control groups.
- Laser Doppler flowmetry (LDF) and oxyhemoglobin saturation (SpO2) measured skin microcirculation.
- Microangiography and survival area analysis demonstrated increased vascular anastomoses and larger survival area in the expanded skin.
Impact:
- External skin expansion promotes robust neovascularization and improves skin viability.
- The findings suggest that external skin expansion is a viable technique comparable to the delay flap.
- This research supports the use of skin expanders in reconstructive surgery by validating their effect on tissue quality and vascularity.