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[Metabolism of angiotensin I in placenta tissue]
Objective:
To explore whether placenta tissue could produce angiotensin I and the metabolism pathway of angiotensin I in placenta.
Methods:
Placenta tissues from 6 term pregnant women without any complication were cultured in vitro for 1 to 6 days, the angiotensin I concentrations in the medium were measured by radioimmunoassay in the first, second, fourth and sixth day. 5 to 500 mumol/l, captopril were added to the culture medium and the concentrations of angiotensin I were measured at the same times to observe the effect of angiotensin converting enzyme on the production of angiotensin I.
Results:
The concentration of angiotensin I in the placenta culture medium increased with the culture time. There were no significant differences in the concentrations, when captopril was added.
Conclusions:
The placenta tissue can produce angiotensin I and its production does not depend on the angiotensin converting enzyme.