[Extraction technology of effervescent granules for arresting cold pain optimized by orthogonal tests]

In the extraction technology of Effervescent Granules for Arresting Cold Pain (Hantongding Paoteng Chongji), the drug combinative modes, solvent pH and drug granularity were optimized by orthogonal tests, with the total alkaloid, paeoniflorin and glycyrrhetinic acid as indexes. The experimental results show that it is better to decoct together all the recipe ingredients, with water of pH2 for the first decoction, then water of pH8 for the second decoction, and to make its granularities ranging from the original herbal pieces to particles which can pass through a No. 2 sieve.