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Related Experiment Videos

Enzymatic activity patterns in probability population samples. Serum lactate dehydrogenase

L Munan, A Kelly, C Petitclerc

    American Journal of Clinical Pathology
    |November 1, 1977
    PubMed
    Summary

    Serum lactate dehydrogenase (LDH) levels vary significantly with age and sex in adults. This study details age- and sex-specific LDH activity in a large population sample.

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    Area of Science:

    • Biochemistry
    • Clinical Chemistry
    • Population Health

    Background:

    • Serum lactate dehydrogenase (LDH) is an enzyme present in many body tissues.
    • Understanding normal LDH levels is crucial for diagnosing various medical conditions.
    • Population-specific reference ranges are essential for accurate clinical interpretation.

    Purpose of the Study:

    • To establish sex- and age-specific reference values for serum lactate dehydrogenase (LDH) activity.
    • To investigate the association of LDH levels with age and sex in a large population.
    • To compare LDH activity in this population with findings from other North American regions.

    Main Methods:

    • A multistage area cluster probability sampling scheme was employed.
    • Serum LDH activity was measured in 2,378 individuals aged 10 years and older.

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  • Statistical analysis was performed to determine sex- and age-specific values.

    • Main Results:

    • Serum LDH activity exhibits distinct patterns across different age groups, with elevations in preadolescents, a decrease in adolescents, and a gradual increase in adults and the elderly.
    • Males generally show higher mean serum LDH activity than females until approximately age 50.
    • Unusually high serum LDH activities were observed in this population compared to other North American studies.

    Conclusions:

    • Serum LDH levels are significantly influenced by both age and sex.
    • The established reference ranges provide valuable data for clinical and research purposes.
    • Observed higher LDH activities warrant further investigation into potential population-specific factors.