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Related Experiment Videos

Urinary glucose and vitamin C

R Brandt, K E Guyer, W L Banks

    American Journal of Clinical Pathology
    |November 1, 1977
    PubMed
    Summary
    This summary is machine-generated.

    High-dose vitamin C supplements can interfere with urine glucose tests, causing incorrect results. This may affect diabetes management, but anion exchange can correct these errors.

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    Area of Science:

    • Clinical Chemistry
    • Nutritional Science
    • Medical Diagnostics

    Background:

    • Self-prescribed high doses of vitamin C are increasingly popular.
    • Elevated urinary vitamin C can interfere with standard clinical diagnostic methods.
    • Accurate urinary glucose monitoring is crucial for managing conditions like diabetes.

    Purpose of the Study:

    • To investigate the interference of high-dose vitamin C with common urinary glucose tests.
    • To evaluate the impact of this interference on diagnostic accuracy.
    • To identify methods for correcting inaccurate test results.

    Main Methods:

    • Utilized coupled-enzyme-chromogen strip tests and Benedict's reagent for glucose detection.
    • Tested urine samples from diabetic and non-diabetic individuals with varying vitamin C intake.

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  • Introduced controlled concentrations of vitamin C into normal urine samples.
  • Employed a simple anion exchange method for urine treatment.

    • Main Results:

    • Coupled-enzyme-chromogen tests showed false-negative glucose results with urinary vitamin C at 200 mg/dl.
    • Benedict's reagent produced false-positive glucose results at vitamin C concentrations of 250 mg/dl and above.
    • These interferences pose a significant challenge for diabetes diagnosis and management.

    Conclusions:

    • High vitamin C intake can lead to erroneous urinary glucose test results.
    • Standard glucose monitoring methods are susceptible to interference from vitamin C.
    • Anion exchange offers a viable method to correct these vitamin C-induced interferences.